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Anti-Thyroid Drugs Carbimazole Tablet

Basic Info

Model No.:  carb-1

Product Description

Model NO.: carb-1 Usage Mode: For oral administration State: Solid Type: Biological Products Color: as Your Requirement Specification: 5mg HS Code: 3001200090 Application: Internal Medicine Suitable for: Elderly, Adult Shape: Tablet Pharmaceutical Technology: Chemical Synthesis Trademark: OEM Origin: China Anti-Thyroid Drugs Carbimazole Tablet
strength 5mg
Carbimazole is used to treat hyperthyroidism. Carbimazole is a pro-drug as after absorption it is converted to the active form, methimazole. Methimazole prevents thyroid peroxidase enzyme from coupling and iodinating the tyrosineresidues on thyroglobulin, hence reducing the production of the thyroid hormones T3 and T4 (thyroxine).
Precautions:
Some people are allergic to azole(s). Some azole drugs have adverse side-effects. Some azole drugs may disrupt estrogenproduction in pregnancy, affecting pregnancy outcome.[1][verification needed]
Carbimazole should be used judiciously in pregnancy as it crosses the placenta. It has (rarely) been associated with congenital defects, including aplasia cutis of the neonate but is not contra-indicated. However, it more predictably may cause fetal hypothyroidism so (in minimal doses) it can be used in order to control maternal hyperthyroidism. There are reported cases of goiter and choanal atresia in fetus.[2] Furthermore, breast feeding is possible but only if lowest effective dose is used and neonatal development is closely monitored.
For the above reasons, it is preferable to use PTU in pregnancy, especially in the first trimester, with the possibility of changing to Carbimazole for the second and third trimesters. 

Adverse effects:
Whilst rashes and pruritus are common, these can often be treated with antihistamines without stopping the carbimazole. For those patients where sensitivity reactions can not be controlled, propylthiouracil may be used as an alternative; cross-sensitivity between these drugs is rare.
Its most serious rare side effect is bone marrow suppression causing neutropenia and agranulocytosis. This may occur at any stage during treatment and without warning; monitoring of white cell count is not useful. Patients are advised to immediately report symptoms of infection, such as sore throat or fever, so that afull blood count test may be arranged. If this confirms a low neutrophil count, discontinuation of the drug leads to recovery. However failure to report suggestive symptoms or delays in considering the possibility of immunosuppression and its testing, can lead to fatalities.

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