Effective Antibiotic Cefixim / Cefixima Capsule for Bacterial Infections
Model No.: DAWAEAC0001
Cefixim is an antibiotic useful for the treatment of a number of bacterial infections. It is a third generation cephalosporin. It is on the World Health Organization's List of Essential Medicines.
Cefixim treats infections of the:
Ear: Otitis caused by Haemophilus influenzae, Moraxella catarrhalis and Streptococcus pyogenes.
Throat: Tonsillitis, pharyngitis caused by Streptococcus pyogenes.
Chest and lungs: Bronchitis, pneumonia caused by Streptococcus pneumoniae and Haemophilus influenzae.
It is also used to treat typhoid fever.
Spectrum of bacterial susceptibility
Cefixim is a broad spectrum cephalosporin antibiotic and is commonly used to treat bacterial infections of the ear, urinary tract, and upper respiratory tract. The following represents MIC susceptibility data for a few medically significant microorganisms:
Escherichia coli: 0.015 µg/mL - 4 µg/mL
Haemophilus influenzae: ≤0.004 µg/mL - >4 µg/mL
Proteus mirabilis: ≤0.008 µg/mL - 0.06 µg/mL
Mechanism of action
The bactericidal action of Cefixim is due to the inhibition of cell wall synthesis. It binds to one of the penicillin binding proteins (PBPs) which inhibits the final transpeptidation step of the peptidoglycan synthesis in the bacterial cell wall, thus inhibiting biosynthesis and arresting cell wall assembly resulting in bacterial cell death.
Only 40-50% is absorbed from the GI tract (oral bioavailability). Absorption may be decreased when taken with food. Average peak concentration after administration of oral suspension is approximately 25-50% greater than the peak concentration following oral tablet or capsules administration.
It has high concentrations in bile and urine. It can cross the placenta and its protein binding capacity is 65%.[medical citation needed]
It is always better to perform appropriate cultures and susceptibility studies to determine the causative organism and its sensitivity to cefixim.
Cefixim is contraindicated in patients with known sensitivity or allergies to cephalosporin class of Antibiotics. As Cefixim is a third generation cephalosporin, it is not contraindicated for patients with a true penicillin allergy.
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Product Categories : Antibiotics
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