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High Quality Pharmaceutical Chemical for Antimalaria Amodiaquine Tablet

Basic Info

Model No.:  DAWAGSH549

Product Description

Model NO.: DAWAGSH549 Usage Mode: For oral administration Shape: Tablet Pharmaceutical Technology: Chemical Synthesis Specifications: 200mg+200mg /100mg+400mg/50mg+135mg Storage: Below 30 Degree MOQ: 1 Box Inspection: Acceptable Transport Package: 3+3/Blister/Box Origin: France Application: Internal Medicine State: Solid Type: Biological Products Name: Amodiaquine Tablet Packing: 3+3/Blister/Box Caution: Consult Your Doctor Useage: Antimalaria Trademark: DAWA Specification: GMP/WHO GMP/EURO GMP HS Code: 3003902000
Name Name
Specification 200mg+200mg
Package 3+3/blister/box



It is bioactivated hepatically to its primary metabolite, N-desethylamodiaquine, by the cytochrome p450 enzyme CYP2C8. Among amodiaquine users, several rare but serious side effects have been reported and linked to variants in the CYP2C8 alleles. CYP2C8*1 is characterized as the wild-type allele, which shows an acceptable safety profile, while CYP2C8*2, *3 and *4 all show a range of "poor metabolizer" phenotypes. People who are poor metabolizers of amodiaquine display lower treatment efficacy against malaria, as well as increased toxicity.[5] Several studies have been conducted to determine the prevalence of CYP2C8 alleles amongst malaria patients in East Africa, and have tentatively shown the variant alleles have significant prevalence in that population.[6] About 3.6% of the population studied showed high risk for a poor reaction to or reduced treatment outcomes when treated with amodiaquine. This information is useful in developing programs of pharmacovigilance in East Africa, and have important clinical considerations for prescribing antimalarial medications in regions with high CYP2C8 variant frequency.   

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