FDA Approved Anesthetic Benzocaine Medicine for Pain Reliever China Manufacturer

New Products

Home > Products > Antipyretic & Analgesic Drug > FDA Approved Anesthetic Benzocaine Medicine for Pain Reliever

FDA Approved Anesthetic Benzocaine Medicine for Pain Reliever

Basic Info

Model No.: HEA751829M4

Product Description

Model NO.: HEA751829M4 Usage Mode: For external use State: Liquid Type: Biological Products Name: Benzocaine MOQ: 1 Box Port: Guangzhou Quality Standard: GMP/Who GMP/Euro GMP Trademark: guyenne Origin: France Application: Internal Medicine Suitable for: Elderly, Children, Adult Shape: Ampoules Pharmaceutical Technology: Chemical Synthesis Brand&Origin: Guyenne, France Sample: Acceptable Delivery Time: 15 Days Shelf Life: 36 Months Specification: GMP/WHO GMP/EURO GMP HS Code: 3001909091
Benzocaine is a local anesthetic commonly used as a topical pain reliever or in cough drops. It is the active ingredient in many over-the-counter anesthetic ointments such as products for oral ulcers. It is also combined with antipyrine to form A/B otic drops to relieve ear pain and remove earwax.

1 Chemical properties

Chemical properties
Benzocaine is the ethyl ester of p-aminobenzoic acid (PABA). It can be prepared from PABA and ethanol by Fischer esterification or via the reduction of ethyl p-nitrobenzoate. Benzocaine is sparingly soluble in water; it is more soluble in dilute acids and very soluble in ethanol, chloroform . The melting point of benzocaine is 88-90 °C, and the boiling point is about 310 °C. The density of benzocaine is 1.17 g/cm3.

2 History

History
Benzocaine was first synthesized in 1890 by the German chemist Eduard Ritsert (1859-1946), in the town of Eberbach and introduced to the market in 1902 under the name "Anästhesin".

3 Mechanism of action

Mechanism of action
Pain is caused by the stimulation of free nerve endings. When the nerve endings are stimulated, sodium enters the neuron, causing depolarization of the nerve and subsequent initiation of an action potential. The action potential is propagated down the nerve toward the central nervous system, which interprets this as pain. Benzocaine acts to inhibit the voltage-dependent sodium channels (VDSCs) on the neuron membrane, stopping the propagation of the action potential.

4 Uses

Benzocaine is indicated to treat a variety of pain-related conditions. It may be used for:
Local anesthesia of oral and pharyngeal mucous membranes (sore throat, cold sores, mouth ulcers, toothache, sore gums, denture irritation)
Otic Pain (earache)
Surgical or procedural local anesthesia

5 Formulations

Benzocaine can come in a variety of preparations including:
Oral preparations:
Lozenges (ex. Cepacol, Mycinettes)
Topical preparations:
Aerosol (ex. Topex)
Gel (ex. Orajel)
Paste (ex. Orabase)
Otic preparations:
Solution (ex. Allergen)

6 Side effects

Benzocaine is generally well-tolerated and non-toxic when applied topically as recommended.
However, there have been reports of serious, life-threatening adverse effects (e.g., seizures, coma, irregular heart beat, respiratory depression) with over-application of topical products or when applying topical products that contain high concentrations of benzocaine to the skin.

7 Other uses

Jiffy Toothache Drops bottle (7.75% Benzocaine)
Benzocaine is used as a key ingredient in numerous Pharmaceuticals:
Some glycerol-based ear medications for use in removing excess wax as well as relieving ear conditions such as otitis media and swimmers ear.
Some previous diet products such as Ayds.
Some condoms designed to prevent premature ejaculation. Benzocaine largely inhibits sensitivity on the penis, and can allow for an erection to be maintained longer (in a continuous act) by delaying ejaculation. Conversely, an erection will also fade faster if stimulus is interrupted.
Benzocaine mucoadhesive patches have been used in reducing orthodontic pain.
In Poland it is included, together with menthol and zinc oxide, in the liquid powder (not to be confused with the liquid face powder) used mainly after mosquito stings. Today's ready made Pudroderm was once used there as pharmaceutical compound.
Benzocaine is commonly found, particularly in Britain, as an impurity in street . Whilst giving a numbing effect similar to on users' gums it does not actually produce the effects of . Also benzocaine can and has been mistaken for a false positive for .

8 Synthesis

Prepd by the esterification of p-aminobenzoic acid: by the reduction of ethyl p-nitrobenzoate:
Benzocaine can be prepared by esterfication using 4-aminobenzoic acid and ethanol. It can also be prepared by reduction of ethyl 4-nitrobenzoate to the amine.
In industrial practice, the reducing agent is usually iron and water in the presence of a little acid.

Dawa Pharm Co., Ltd.

Contact us if you need more details on Anbesol. We are ready to answer your questions on packaging, logistics, certification or any other aspects about Analgesia、Anesthetic. If these products fail to match your need, please contact us and we would like to provide relevant information.

Product Categories : Antipyretic & Analgesic Drug

Premium Related Products